China needs more than 2000 kinds of raw materials and intermediates supporting chemical industry every year, and the demand is more than 2.5 million tons. After more than 30 years of development, the chemical raw materials and intermediates required for pharmaceutical production in China can be basically matched, and only a small part needs to be imported. Moreover, due to China's rich resources and low prices of raw materials, many intermediates have been exported in large quantities. So, what are the development opportunities in the field of pharmaceutical intermediates in China?
Increased demand
our country β－ After nearly 50 years of development, lactam antibiotics have formed a complete production system. Almost all β－ All lactam antibiotics (except those within the patent period) can be produced in China, and the cost is very low. Penicillin production ranks first in the world, and a large number of them are exported to the international market; Cephalosporins are basically self-sufficient, and some of them can be exported.
2012, and β－ All the supporting intermediates of lactam antibiotics can be produced by China itself. Except that the mother nuclei of semi synthetic antibiotics, 7-ACA and 7-ADCA, need to be partly imported, all the side chain intermediates can be produced and exported in large quantities.
with β－ As an example, phenylacetic acid, the main supporting intermediate of lactam antibiotics, has nearly 30 phenylacetic acid manufacturers in China, with a total annual production capacity of about 20000 tons. However, most enterprises are small in scale, with the largest annual output of 2000 tons, and most others produce hundreds of tons. In 2003, the total domestic demand for phenylacetic acid was about 14000 tons, and the consumption structure was: penicillin G accounted for 85%, other medicines accounted for 4%, spices accounted for 7%, and pesticides and other fields accounted for 4%.
With the development of domestic spice, medicine, pesticide and other industries, the demand for phenylacetic acid will further increase. It is estimated that by 2005, the pharmaceutical industry in China will consume about 14000 tons of phenylacetic acid, the pesticide industry will consume 500 tons, and the spice industry will consume about 2000 tons. In addition to the consumption in other fields, the total domestic demand for phenylacetic acid is expected to reach 18000 tons in 2005.